You can print double-sided if your printer supports double-sided (duplex printing) feature.  

Note: Double-sided printing is also called duplex, back-to-back, front-and-back, or two-sided printing. The printer driver controls the options, not Adobe Acrobat or Adobe Reader. Check your printer documentation to see what features your printer supports.

• Press Ctrl + P (Windows) or command + P (macOS) to open the Print dialog box. In the Print dialog box, select Print on both sides of paper, and choose an edge to Flip.

You can print a color PDF in shades of gray (also known as grayscale or composite gray).

You can scale the page to shrink or enlarge pages when you print. You can automatically scale to fit the paper or manually scale by percentages

• Press Ctrl + P (Windows) or command + P (macOS) to open the Print dialog box.
  In the Print dialog box, click Size and then specify the scaling options.

Fit  Reduces or enlarges each page to fit the printable area of the currently selected paper size. For PostScript® printers, the PPD determines the printable area of the paper.

Actual Size  Prints the pages without scaling. Pages or selections that don’t fit on the paper are cropped. You can set this option as the default using the None print preset. See Create print presets.

Shrink Oversize Pages Shrinks large pages to fit the currently selected paper size but doesn’t enlarge small pages. If an area is selected and is larger than the printable area of the currently selected paper, it’s scaled to fit the printable area. This option is always active during N-up printing. You can set this option as the default using the Default print preset. See Create print presets.

Custom Scale  Resizes the page by the percentage you specify.

Choose Paper Source By PDF Page Size (Windows)  Uses the PDF page size to determine the output tray rather than the page setup option. This option is useful for printing PDFs that contain multiple page sizes on printers that have different-sized output trays.

You can print a large format document, such as a poster or banner, by splitting the page across multiple sheets of paper (called "tiling"). The Poster option calculates how many sheets of paper are needed. You can adjust the size of the original to best fit the paper and specify how much each "tile" overlaps. You can then piece together the tiles.

• Press Ctrl + P (Windows) or command + P (macOS) to open the Print dialog box.
  In the Print dialog box, click Poster and then specify the tiling options.

Tile Scale  Scales the pages by the amount you specify.

Overlap Determines the amount each tile overlaps adjacent tiles.

Cut Marks Adds guide marks to each page to help you trim the overlap.

Labels Adds the filename and page number on each "tile."

Tile Only Large Pages  Applies tiling to pages that are larger than the selected paper size at the specified scale. These pages are mapped to multiple sheets of paper.

You can print more than one page of a PDF onto a single sheet of paper. Printing multiple pages per sheet is also called n-up printing (such as 2-up or 6-up). You can specify how the pages are ordered, either horizontally across the page or in vertical columns.

Pages Per Sheet  Prints a predefined number of pages, or a custom number (up to 99), horizontally and vertically. If you select a predefined number from the menu, Acrobat automatically selects the best paper orientation.

Page Order  Defines how the pages are ordered on paper. Horizontal places pages from left to right, top to bottom. Horizontal Reversed places pages from right to left, top to bottom. Vertical places pages top to bottom, left to right. Vertical Reversed places pages top to bottom, right to left. Both reversed options are suitable for Asian-language documents.

Print Page Border  Prints the crop box (the page boundary of PDF pages).

Note: Printing multiple pages per sheet in Acrobat is independent of the N-up printing features of printer drivers. The Acrobat print settings don’t reflect the N-up settings of the printer drivers. Select the multple pages options either in Acrobat or in the printer driver, but not both.

You can print a multipage document as a booklet. The pages are laid out two per sheet. When you collate, fold, and staple the double-sided sheets, the result is a single book with the correct page order.

• Press Ctrl + P (Windows) or command + P (macOS) to open the Print dialog box.
  In the Print dialog box, click Booklet and then specify the booklet options.
  

For more information, see Print Booklets and PDF Portfolios.